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Vol. 9, No. 6, pp. 402-407, November/December 2002
Department of Physiology, Ponce School of Medicine,
Ponce, Puerto Rico, 00732
Conditioned fear responses to a tone paired with footshock rapidly
extinguish when the tone is presented in the absence of the shock.
Rather than erase conditioning, extinction is thought to involve the
formation of new memory. In support of this, extinguished freezing
spontaneously recovers with the passage of time. It is not known,
however, how long extinction memory lasts or whether extinction
interferes with consolidation of conditioning if given on the same day.
To address this, we gave rats 7 trials of auditory fear conditioning
followed 1 h later by 20 extinction trials, and tested for spontaneous
recovery after a delay of 0, 1, 2, 4, 6, 10, or 14 d. Conditioned
freezing to the tone gradually recovered with time to reach 100% by
day 10. No-extinction controls indicated that the increase in freezing
with time was not owing to incubation of conditioning memory. Complete
spontaneous recovery indicates that extinction training given 1 h after
conditioning does not interfere with the consolidation of conditioning
memory. Despite complete recovery of freezing, rats showed savings in their rate of re-extinction, indicating persistence of extinction memory. These data support the idea that conditioning and extinction of
fear are learned by independent systems, each able to retain a
long-term memory.
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