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Vol. 6, No. 2, pp. 177-192, March/April 1999
Department of Biology and Volen Center for Complex Systems, Brandeis University, Waltham, Massachusetts 02454-9110 USA
Globally inhibiting CaM kinase activity in Drosophila, using
a variety of genetic techniques, disrupts associative memory yet leaves
visual and chemosensory perception intact. These
studies implicate CaM kinase in the plastic processes underlying
learning and memory but do not identify the neural circuitry that
specifies the behavior. In this study, we use the
GAL4/UAS binary expression system to define areas of the
brain that require CaM kinase for modulation of courtship conditioning.
The CaM kinase-dependent neurons that determine the response to the
mated female during conditioning and those involved in formation and
expression of memory were found to be located in distinct areas of the
brain. This supports the idea that courtship conditioning results in two independent behavioral modifications: a decrement in courtship during the conditioning period and an associative memory of
conditioning. This study has allowed us for the first time to
genetically determine the circuit of information flow for a memory
process in Drosophila. The map we have generated dissects the
behavior into multiple components and will provide tools that allow
both molecular and electrophysiological access to this circuit.
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