HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) All Versions of this Article: lm.84805v1 12/3/352    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Bjorness, T. E. Articles by Poe, G. R. Search for Related Content PubMed PubMed Citation Articles by Bjorness, T. E. Articles by Poe, G. R. Social Bookmarking                   What's this?

Research Paper
REM restriction persistently alters strategy used to solve a spatial task

Theresa E. Bjorness¹, Brett T. Riley², Michael K. Tysor² and Gina R. Poe^2,3,4

¹ Neuroscience Program,² Department of Anesthesiology, and³ Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, Michigan 48014, USA

We tested the hypothesis that rapid eye movement (REM) sleep is important for complex associative learning by restricting rats from entering REM sleep for 4 h either immediately after training on an eight-box spatial task (0-4 REMr) or 4 h following training (4-8 REMr). Both groups of REM-restricted rats eventually reached the same overall performance level as did nonrestricted controls, but 0-4 REMr animals were delayed in their improvement in the first few days and lagged behind controls in the middle portion of the training period. More importantly, performance gains of 0-4 REMr rats depended more on simple local cues throughout the 15-d study since, unlike control and 4-8 REMr animals, their error rate increased after daily disruption of the relationship between local (intramaze) cues and the food reward. Thus, although overall performance was only subtly and transiently impaired, due to the ability to use alternate, nonspatial behavioral strategies, complex associative (spatial) learning was persistently impaired by restricting REM for a short critical period each day.

Article published online ahead of print. Article and publication date are at http://www.learnmem.org/cgi/doi/10.1101/lm.84805.

Corresponding author.

⁴ E-mail ginapoe{at}umich.edu; fax (734) 764-9332.

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

This article has been cited by other articles:

				R. Guzman-Marin, Z. Ying, N. Suntsova, M. Methippara, T. Bashir, R. Szymusiak, F. Gomez-Pinilla, and D. McGinty Suppression of hippocampal plasticity-related gene expression by sleep deprivation in rats J. Physiol., September 15, 2006; 575(3): 807 - 819. [Abstract] [Full Text] [PDF]

				E. M. Robertson and D. A. Cohen Understanding Consolidation through the Architecture of Memories Neuroscientist, June 1, 2006; 12(3): 261 - 271. [Abstract] [PDF]

				I. S. Hairston, M. T. M. Little, M. D. Scanlon, M. T. Barakat, T. D. Palmer, R. M. Sapolsky, and H. C. Heller Sleep Restriction Suppresses Neurogenesis Induced by Hippocampus-Dependent Learning J Neurophysiol, December 1, 2005; 94(6): 4224 - 4233. [Abstract] [Full Text] [PDF]