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Research Paper
A role for prefrontal calcium-sensitive protein phosphatase and kinase activities in working memory

Jason D. Runyan, Anthony N. Moore and Pramod K. Dash¹

The Vivian L. Smith Center for Neurological Research, Department of Neurobiology and Anatomy, The University of Texas Medical School, Houston, Texas 77225, USA

The prefrontal cortex is involved in the integration and interpretation of information for directing thoughts and planning action. Working memory is defined as the active maintenance of information in mind and is thought to lie at the core of many prefrontal functions. Although dopamine and other neurotransmitters have been implicated, the intracellular events activated by their receptors that influence working memory are poorly understood. We demonstrate that working memory involves transient changes in prefrontal G_q/11-signaling and in calcium-dependent intracellular protein phosphatase and kinase activity. Interestingly, inhibition of the calcium activated phosphatase calcineurin impaired, while calcium/calmodulin dependent kinase II (CaMKII) and calcium-dependent protein kinase C (PKC) enhanced, working memory. Our findings suggest that the active maintenance of information required for working memory involves transient changes in the balance of these enzymes' activities.

Article and publication are at http://www.learnmem.org/cgi/doi/10.1101/lm.89405.

Corresponding author.

¹ E-mail p.dash{at}uth.tmc.edu; fax (713) 500-0621.

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