LEARNING & MEMORY 11:540-543
©2004 by Cold Spring Harbor Laboratory Press; ISSN 1072-0502/04 $5.00
Brief Communication
Postextinction Infusion of a Mitogen-Activated Protein Kinase Inhibitor Into the Medial Prefrontal Cortex Impairs Memory of the Extinction of Conditioned Fear
Sandrine Hugues,
Olivier Deschaux and
René Garcia1
Neurobiologie Comportementale, JE Neurobiologie &
Psychopathologie, Université de Nice-Sophia Antipolis, 06108 Nice,
France
ABSTRACT
We investigated whether postextinction training infusion of PD098059, a
selective inhibitor of mitogen-activated protein kinase (MAPK) activation,
into the medial prefrontal cortex, would impair retention of extinction
learning in rats. We found that immediate, but not late (2 or 4 h),
postextinction infusion of PD098059 provoked a full return of conditioned
freezing. These results suggest that activation of prefrontal MAPK in early
stages of postextinction training participates in processes that protect
against spontaneous recovery of aversive responses.
Received March 30, 2004;
accepted in revised form July 8, 2004.
FOOTNOTES
Article and publication are at
http://www.learnmem.org/cgi/doi/10.1101/lm.77704.
Corresponding author.
1
E-MAIL
rene.garcia{at}unice.fr;
FAX 33-4-9207-6162.
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