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Brief Communication
Like Extinction, Latent Inhibition of Conditioned Fear in Mice Is Blocked by Systemic Inhibition of L-Type Voltage-Gated Calcium Channels

Mark Barad^1,3, Ashley M. Blouin² and Chris K. Cain²

¹ Department of Psychiatry and Biobehavioral Sciences, Brain Research Institute and Neuropsychiatric Institute, and² Interdepartmental Program in Neuroscience, University of California, Los Angeles, Los Angeles, California 90095-1761, USA

ABSTRACT

Having recently shown that extinction of conditioned fear depends on L-type voltage-gated calcium channels (LVGCCs), we have been seeking other protocols that require this unusual induction mechanism. We tested latent inhibition (LI) of fear, because LI resembles extinction except that cue exposures precede, rather than follow, cue-shock pairing. Systemic injections of two LVGCC inhibitors, nifedipine and diltiazem, before pre-exposure blocked LI completely with no evidence of state-dependent learning. The results indicate that extinction and LI share a common molecular requirement and may support the notion that LI, like extinction, is a form of inhibitory learning.

FOOTNOTES

Article and publication are at http://www.learnmem.org/cgi/doi/10.1101/lm.78304.

Corresponding author.

³ E-MAIL mbarad{at}mednet.ucla.edu; FAX (310) 267-0040.

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This article has been cited by other articles:

				C. K. Cain, B. P. Godsil, S. Jami, and M. Barad The L-type calcium channel blocker nifedipine impairs extinction, but not reduced contingency effects, in mice Learn. Mem., May 1, 2005; 12(3): 277 - 284. [Abstract] [Full Text] [PDF]